Characterization of a Novel Isoform of α-Nascent Polypeptide-associated Complex as IgE-defined Autoantigen
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چکیده
منابع مشابه
Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria.
To identify yeast cytosolic proteins that mediate targeting of precursor proteins to mitochondria, we developed an in vitro import system consisting of purified yeast mitochondria and a radiolabeled mitochondrial precursor protein whose C terminus was still attached to the ribosome. In this system, the N terminus of the nascent chain was translocated across both mitochondrial membranes, generat...
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15 صفحه اولDual binding mode of the Nascent Polypeptide-associated Complex (NAC) reveals a novel universal adapter site on the ribosome
Nascent Polypeptide-associated Complex (NAC) was identified in eukaryotes as the first cytosolic factor which contacts the nascent polypeptide chain emerging from the ribosome. NAC is present as a homodimer in Archaea and as a highly conserved heterodimer in eukaryotes. Mutations in NAC cause severe embryonically lethal phenotypes in mice, D. melanogaster and C. elegans. In the yeast Saccharomy...
متن کاملDual binding mode of the nascent polypeptide-associated complex reveals a novel universal adapter site on the ribosome.
Nascent polypeptide-associated complex (NAC) was identified in eukaryotes as the first cytosolic factor that contacts the nascent polypeptide chain emerging from the ribosome. NAC is present as a homodimer in archaea and as a highly conserved heterodimer in eukaryotes. Mutations in NAC cause severe embryonically lethal phenotypes in mice, Drosophila melanogaster, and Caenorhabditis elegans. In ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2002
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2002.00518.x